I met Alice almost by accident. Sunday morning rounds
were nearly completed when I passed Dr. T. in the hallway. We exchanged
pleasantries and then walked on in opposite directions. But, seemingly as an
afterthought, he called out.
“”Do you think you can go by and see a patient for me?
Her name is Alice. She’s in room 402. She’s in the hospital with constipation
and she’s pretty distended. I plan a colonoscopy tomorrow, but, maybe, just
give her a quick look. She had a CT that just showed constipation.”
“Sure,” I replied, “I’m going in that direction
anyway.”
Alice was petite, weighing in at 98 pounds and she
certainly was distended, almost like she was about to deliver twins. She was
46, had always had “bowel trouble,” had previous back surgery and was on
chronic pain medication, taking Percocet several times a day. She had not had
previous abdominal surgery.
“Does your abdomen hurt?” I began.
“All over, but the Dilaudid helps,” she replied.
“When did the pain start?”
“About three weeks ago, but it got worse three days
ago.”
“When’s the last time you had a bowel movement?”
“Nine weeks before I came into the hospital.”
I had to stop for a moment to completely absorb this
statement.
I
think this is a record.
“Did you say nine weeks?” I asked again.
“Yes, nine weeks.”
“…and you’ve been here three days, so it’s been nine
and half weeks since you had a BM? Is that unusual for you?”
“Normally I go every three or four days. I did start
to panic after a week, but I didn’t know what to do.”
“Are you able to pass gas?”
“I’m not sure.”
“Let me check your abdomen.”
She was extremely distended and had diffuse
tenderness, and some signs of peritonitis, particularly tenderness to light
percussion on the right side of her abdomen.
“I’m going to look at your CAT Scan and then I’ll be
back.”
So
much for getting rounds done at a reasonable time.
The CT Scan done the day before revealed just what one
would expect in patient who had been constipated for nine and half weeks. The colon
was dilated, filled with stool, but not much air. The cecum, the first part
measured ten centimeters, approaching the diameter where blowout becomes a
concern. The dilated colon stopped in the mid sigmoid colon, which is just
above the rectum. There was no definite tumor or mass, but there was a definite
transition point from dilated to collapsed colon.
I checked her labs next. Her white Blood Cell Count
had been slightly elevated at 12,000 the day before, but today it had jumped up
to 35,000. Her bicarbonate level was 14, which is low, normal being around 25.
Low Bicarbonate suggests metabolic acidosis, a sign of severe metabolic
derangement and sepsis.
Taking everything together there was no question. She
needed surgery. She either had perforated her colon or she had dead or dying
colon. Either way it was a life threatening surgical emergency.
Of course, Sunday is not the best day to get anything
done quickly. There were a series of Orthopedic cases scheduled already.
“I need to do this lady soon,” I explained to the
crew.
“It looks like you’re in luck. Dr. R. just cancelled
his last two cases and we are finishing up with him now,” the OR nurse
reported.
“Good.”
I explained my findings and concerns to Alice and her
family, put her orders in the computer and waited for the OR crew.
Maybe
just a colostomy will suffice. But, it would be better to eliminate the cause
of the obstruction. Quick and simple will be best for her.
After about 25 minutes Alice was wheeled into OR room
ten and was asleep a few minutes later.
A midline incision through the taut abdominal wall
brought me into her abdomen which was filled with a few hundred cc’s of
slightly cloudy yellowish fluid. I could see that the sigmoid colon was
massively dilated, but it was not gangrenous. There was a faint, pungent odor.
Looks
like I should be able to remove the offending portion of colon.
I could see where the colon transitioned to normal
caliber just above the pelvis. I began to mobilize the colon by dividing the peritoneal
attachments that tethered the sigmoid and left colon.
“Feels like there’s a hard mass in the colon causing the
obstruction,” I observed out loud to no one in particular, my assistant nodding
her head,
I should be able to get this colon free and
then…
Before I could finish this thought the dam busted and
I was suddenly up to my elbows in thick, liquid stool.
“Shit…” Literally.
“Suction, lap, more laps, more suction.”
The suction became plugged with stool. I squeezed the
colon closed with my hand and it fell apart. Like The Blob from the 1950’s or
the river of slime from “Ghostbusters” liquid stool took over.
“I need an intestinal clamp, something atraumatic,” I
said loudly.
The circulator scurried out of the room and came back
with the GI instruments. In the meantime I had managed to isolate the source,
rather the sources of the river of stool and began to get at least a semblance
of control.
The evil culprit
rears its ugly head.
“There’s a big rock of poop causing the obstruction,”
I noted.
Indeed, this “fecaloma” had completely blocked the
sigmoid colon and eroded into the wall of the bowel, setting a trap for me as I
mobilized the colon. As soon as the colon was free it exploded, releasing its
noxious contents. The resultant inundation left poop everywhere, on every loop
of bowel and filled the pelvis.
With the proper intestinal clamp in hand I stemmed the
flow and went on with the resection. I had to make two passes with the GIA to
divided the dilated bowel while there was no difficulty dividing the distal
colon, stapling it closed with the RL60 stapler.
Home
free.
I finished resecting the sigmoid colon and examined it
on a separate table.
This
colon is as strong as soggy Kleenex.
“Uh, Dr. Gelber, I think there’s a problem here.”
“What…?”
Liquid stool was filling up the abdomen again.
I hurried back to the cesspool which was Alice’s open
belly and valiantly struggled to stem the flow again. The staples had not held
the friable colon together. Once again, we went to work, sponging and
suctioning until I could see enough to mobilize the colon away from its usual
position on the left side of the abdomen, find the hole and carefully put a
clamp across it.
This time it held, at least enough to allow me to get
my bearings and assess the situation in a calmer, more orderly manner. I made a
closer inspection of the remaining bowel.
The right side of the colon didn’t look very good
either. Muscle fibers in the cecum were split under the tension caused by
massive dilation, the ascending colon had patches of frank gangrene as did the
splenic flexure.
It
all needs to come out.
Back to work. I began by dividing the attachments to
the cecum and was then able to liberate the hepatic flexure with minimal fuss
and the remainder of the colon followed until everything was free. I zipped
through the mesentery with the Ligasure and before long the colon was resting
in a large basin on the back table. At this point we all changed gowns and
gloves and tried to put banish the pungent odor from our nostrils. Even with
benzoin (a fragrant compound often used in surgery) on our masks and repeated
washing of hands I knew that the fine aroma of stool and dead bowel would
linger with me for the rest of the day.
This
nasty beast has been far too much trouble. Time to finish this case.
We spent the next twenty minutes washing, washing and
more washing. Liter upon liter of warm saline was poured, sprayed, percolated
and pumped into every nook and cranny of her abdomen. We squirted irrigation
fluid into the pelvis, above the liver, around the spleen and between every
loop of bowel until the fluid came out as clean as it went in.
Finally, I brought the end of the small bowel out as
an ileostomy, took one more look around her belly and closed her up. Ensconced
safely in the ICU, I washed my hands one more time, wrote orders, dictated the
op note and, last of all, told her family the sordid tale of her surgery.
I called Alice’s Attending physician and consulted one
of the Pulmonary docs, checked on Alice one more time and finally left the
hospital for the day.
Alice was kept on the ventilator, she was very slow to
wake up from anesthesia and her blood pressure hovered in the 80’s;
occasionally dipping into the 70’s. A massive volume of IV fluid and support with
Levophed and Vasopressin were necessary to maintain an acceptable blood
pressure. (These two medications help maintain vascular tone, which helps
maintain blood pressure in patients with septic shock). Her kidneys started to
shut down, but timely adjustment of her fluids and medications by a Renal
consultant turned this around.
The following day she looked a little better, more
awake, good urine output, but still requiring pressor support with Levophed and
Vasopressin. She continued to smolder along over the next 48 hours, neither
improving nor deteriorating. I became a little concerned about her abdomen at
this time as it became more distended and the ileostomy stoma looked dark
purple instead of pink. Her lactic acid level rose to a very high 14, a sign of
worsening acidosis, which indicated seriously poor perfusion of something and
worsening sepsis. Although she maintained adequate blood pressure and kidney
function, it became clear that something was amiss or amuck or afoul.
Alice was taken back to surgery.
The previous wound was opened and a couple of liters
of clear fluid was drained.
That
explains the abdominal distention.
In the lower abdomen there was some cloudy, foul
smelling fluid. As I gently freed up the small bowel and delivered it out of
the abdomen I discovered the new source of Alice’s woes. The distal small bowel
was dead, not completely, but patches had frank gangrene. I resected about 25
centimeters of terminal ileum and redid her ileostomy.
She also had a portion of abdominal wall which was
dying and this also was excised. I put her back together as well as I could and
delivered her to the ICU and hoped for the best.
The next twenty four hours brought hope as she
required less support with the pressors. However, she didn’t wake up.
The following day came with new events which proved to
be too much. She began to have cardiac arrhythmias, frequent Premature
Ventricular Contractions (PVC’s) and runs of, Atrial flutter and Ventricular
Tachycardia. The Cardiology consultant added his words of wisdom to the already
exhaustive list of consultants.
“Acute MI,” he said with a solemn expression on his
face. “Ejection fraction is only 30%,” he said shaking his head.
She’s
not going to make it.
Alice continued along for a couple of more days, but
she didn’t wake up, her kidney function gradually declined and her family
wisely withdrew support, allowing her to pass away.
I wish I could report that timely surgery had rescued
Alice. I don’t know how many similar patients I’ve taken care of, how many
times I’ve told families “We’ve eliminated the source of infection; the
perforation, the blockage, the gangrene, the abscess; now it’s time to heal.”
Very often it’s this healing phase which proves to be
too much. Organ systems which have suffered the supreme shock of serious
systemic infection are unable to recover and gradually shut down. The initial
sepsis leads to what is called multi organ system dysfunction which progresses
to multi organ failure which often leads to death.
After I finish operations such as Alice’s I’ve learned
not to say: “Alice (or Andy or Mabel or anyone) will be better now.”
I’ve learned that the human body often does not suffer
lightly intrusions by combinations of bile, blood, GI contents or urine mixed
with microorganisms which thrive in such an environment. The body does its best
to fight such invasions and may be successful. But, sometimes as the battle is
fought and the war looks like it will be won, the body dies.
And, nine and a half week’s worth of poop is more than
most of us could handle.